EFFECTS OF 3'-C-METHYLATION ON THE HYDROLYTIC STABILITY AND HYDROXYL PK(A) VALUES OF DINUCLEOSIDE 2',5'-MONOPHOSPHATE AND 3',5'-MONOPHOSPHATE

Authors
OIVANEN M EFIMTSEVA EV MIKHAILOV SN
Citation
M. Oivanen et al., EFFECTS OF 3'-C-METHYLATION ON THE HYDROLYTIC STABILITY AND HYDROXYL PK(A) VALUES OF DINUCLEOSIDE 2',5'-MONOPHOSPHATE AND 3',5'-MONOPHOSPHATE, Nucleosides & nucleotides, 17(8), 1998, pp. 1325-1331
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
8
Year of publication
1998
Pages
1325 - 1331
Database
ISI
SICI code
0732-8311(1998)17:8<1325:EO3OTH>2.0.ZU;2-6
Abstract
The first-order rate constants for hydrolysis of 3'-C-methyluridylyl(2 ',5')- and -(3',5')adenosine and the corresponding native dinucleoside monophosphates (2',5'- and 3',5'-UpA) have been determined as a funct ion of hydroxide-ion concentration (0.025 - 7 M) at 25 degrees C. In a ddition to the effects on the hydrolytic stability of the compounds, t he effects of the 3'-C-methyl substitution on the kinetically determin ed pK(a) values for the sugar hydroxyls of the uridine moiety are disc ussed.