POTENTIAL ANTIVIRAL AGENTS - PART II - SYNTHESIS AND ANTIVIRAL EVALUATION OF PYRAZINONES SUBSTITUTED WITH ACYCLIC CHAINS

Authors
DAVIS J BENHADDOU R FEDORYAK O GRANET R KRAUSZ P BLIARD C DEMONTE M AUBERTIN AM
Citation
J. Davis et al., POTENTIAL ANTIVIRAL AGENTS - PART II - SYNTHESIS AND ANTIVIRAL EVALUATION OF PYRAZINONES SUBSTITUTED WITH ACYCLIC CHAINS, Nucleosides & nucleotides, 17(8), 1998, pp. 1489-1504
Citations number
45
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
8
Year of publication
1998
Pages
1489 - 1504
Database
ISI
SICI code
0732-8311(1998)17:8<1489:PAA-PI>2.0.ZU;2-9
Abstract
The synthesis of a series of 4'-substituted hydroxybutyl pyrazine anal ogues of the anti-herpes compound, acyclovir, is described. The compou nds were characterized with H-1 and C-13 nmr, mass and IR spectroscopy . Antiviral (HSV-1, CMV, Cox B4, HIV-I) properties of these compounds were examined. None of these compounds were active against these virus es.