NONCANONICAL STRUCTURAL ELEMENTS OF PROMOTER DNA AND THEIR ROLE IN COMPLEX-FORMATION WITH RNA-POLYMERASE

Authors
OZOLINE ON DEEV AA
Citation
On. Ozoline et Aa. Deev, NONCANONICAL STRUCTURAL ELEMENTS OF PROMOTER DNA AND THEIR ROLE IN COMPLEX-FORMATION WITH RNA-POLYMERASE, Molecular biology, 32(3), 1998, pp. 358-362
Citations number
15
Categorie Soggetti
Biology
Journal title
Molecular biology → ACNP
ISSN journal
00268933
Volume
32
Issue
3
Year of publication
1998
Pages
358 - 362
Database
ISI
SICI code
0026-8933(1998)32:3<358:NSEOPD>2.0.ZU;2-C
Abstract
Promoter sequences were studied by cluster analysis, Five regions with nonrandom base distribution were found, and their typical structural elements were revealed, Some of these elements were homologous to the sequences located near the promoter regions, which, in a complex with RNA polymerase, displayed hypersensitivity to DNase I. Since near such sites the enzyme tightly contacts the promoter DNA, the physicochemic al features of the found sequences may determine the specificity of th e interaction of RNA polymerase with different promoters.