ASSESSMENT OF POSSIBLE NEPHROTOXICITY FROM IOHEXOL IN PATIENTS WITH NORMAL AND IMPAIRED RENAL-FUNCTION

Purpose. To evaluate the possible nephrotoxic effects of iohexol in pa tients with normal and impaired renal function. Material and Methods: A prospective urographic study using iohexol (50 ml, 300 mg I/ml) was performed in 100 patients, 63 with impaired renal function (IRF) and 3 7 with normal renal function (NRF). The group included 24 patients wit h diabetes mellitus, 17 of them with IRE Renal function parameters and adverse events were recorded for one week after the urography. Result s: There were no significant changes in serum creatinine, creatinine c learance, or beta-2-microglobulin. The 24-h urine protein excretion sh elved a statistically significant increase in patients with NRF as wel l as in patients with IRE Nine patients experienced adverse events but none of them required any treatment. Conclusion. Iohexol was tolerate d well in patients with NRF and in patients with IRF without significa nt overall nephrotoxic effects. Some minor adverse events were recorde d.