IODIXANOL IS READILY ELIMINATED BY HEMODIALYSIS

Purpose, Material and Methods, and Results: The dialyzability of the h igh-molecular X-ray contrast medium iodixanol was examined in an in vi tro hemodialysis model using two different hollow fiber membranes: one high-flux (polysulfone) membrane and one intermediate-flux (cellulose triacetate) membrane. Blood flow was 200 ml/min and membrane area 1.3 m(2). The dialyzer clearance of iodixanol dissolved in a mixture of l eukocyte-filtered SAG-M blood and compatible citrate plasma was 134.2/-3.6 ml/min for the polysulfone membrane and 113.0+/-3.6 ml/min for t he cellulose triacetate membrane. Conclusion. Iodixanol is readily dia lyzed through commercial high-flux membranes.