Purpose: To evaluate the capability of color Doppler ultrasonography t
o differentiate between benign and malignant soft-tissue tumors. Mater
ial and Methods: We reviewed the ultrasonographic (US) and color Doppl
er (CD) findings in 46 consecutive patients with a palpable periskelet
al mass. The presence of 3 or more vascular hila and of tortuous and i
rregular internal vessels within the lesions was considered an indicat
ion of malignancy. The CD diagnosis was compared with that obtained at
US alone. Results: The sensitivity and specificity of CD were respect
ively 85% and 92%; these values were higher than those obtained at US
alone, respectively 75% and 50%. Arteriovenous malformations presented
as lesions with large internal vessels that had low vascular impedanc
e and were easily diagnosed. The waveform patterns within solid tumors
were not specific. Conclusion: At present, US is commonly employed to
confirm the presence of a suspected soft-tissue mass, to locate it ac
curately, and to indicate its nature. CD findings enhance the sole of
the US technique in such lesions. The combined use of US and CD can al
low the differentiation of benign from malignant lesions, and thus pro
vide a better basis for treatment.