ANTERIOR UVEITIS ASSOCIATED WITH LATANOPROST

PURPOSE: To report the association of anterior uveitis with the use of latanoprost. METHODS: We studied four patients with complicated open- angle glaucoma who had anterior uveitis associated with the use of lat anoprost. The uveitis was unilateral and occurred only in the eye rece iving latanoprost in three patients. In one patient, latanoprost was u sed in both eyes, and the uveitis was bilateral. Four of five eyes had a history of prior inflammation and/or prior incisional surgery. All patients were rechallenged with the drug. RESULTS: The uveitis improve d after cessation of latanoprost with or without topical corticosteroi ds. It recurred after rechallenging with latanoprost in all eyes. CONC LUSION: There is a possible association between latanoprost and anteri or uveitis, Topical prostaglandin analogs may be relatively contraindi cated in patients with a history of uveitis or prior ocular surgery. T his association may also be possible in eyes that have not had previou s uveitis or incisional surgery. (C) 1998 by Elsevier Science Inc. All rights reserved.