RECOMBINANT SINDBIS VIRUSES EXPRESSING A CYTOTOXIC T-LYMPHOCYTE EPITOPE OF A MALARIA PARASITE OR OF INFLUENZA-VIRUS ELICIT PROTECTION AGAINST THE CORRESPONDING PATHOGEN IN MICE

Authors
TSUJI M BERGMANN CC TAKITASONODA Y MURATA KI RODRIGUES EG NUSSENZWEIG RS ZAVALA F
Citation
M. Tsuji et al., RECOMBINANT SINDBIS VIRUSES EXPRESSING A CYTOTOXIC T-LYMPHOCYTE EPITOPE OF A MALARIA PARASITE OR OF INFLUENZA-VIRUS ELICIT PROTECTION AGAINST THE CORRESPONDING PATHOGEN IN MICE, Journal of virology, 72(8), 1998, pp. 6907-6910
Citations number
25
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
8
Year of publication
1998
Pages
6907 - 6910
Database
ISI
SICI code
0022-538X(1998)72:8<6907:RSVEAC>2.0.ZU;2-U
Abstract
Subcutaneous administration in mice of recombinant Sindbis viruses exp ressing a class I major histocompatibility complex-restricted 9-mer ep itope of the Plasmodium yoelii circumsporozoite protein or the nucleop rotein of influenza virus induces a large epitope-specific CD8(+) T-ce ll response. This immunization also elicits a high degree of protectio n against infection with malaria or influenza A virus.