CONJUGATE REDUCTION OF ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS - SELECTIVE-INHIBITION OF BENZYL ETHER HYDROGENOLYSIS BY NH4OH MEOH/

Authors
DIAS LC CAMPANO PL
Citation
Lc. Dias et Pl. Campano, CONJUGATE REDUCTION OF ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS - SELECTIVE-INHIBITION OF BENZYL ETHER HYDROGENOLYSIS BY NH4OH MEOH/, Journal of the Brazilian Chemical Society, 9(1), 1998, pp. 97-99
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Journal of the Brazilian Chemical Society → ACNP
ISSN journal
01035053
Volume
9
Issue
1
Year of publication
1998
Pages
97 - 99
Database
ISI
SICI code
0103-5053(1998)9:1<97:CROAC->2.0.ZU;2-V
Abstract
A series of alpha,beta-unsaturated alkyl and aryl ketones, esters and N-methoxy-N-methyl-amides (Weinreb amides) containing an O-benzyl prot ecting group undergo conjugate reduction by H-2/Pd/C in the presence o f 2N NH4OH/MeOH at room temperature and ordinary pressure leaving the benzyl group intact.