The courses of two neonates treated with intravenous amiodarone for su
praventricular tachyarrhythmia, both of whom developed significant adv
erse effects, are reported. A 13-day-old term newborn developed hypoth
yroidism after 27 days of mostly intravenous amiodarone for atrioventr
icular reciprocating tachycardia and severe heart failure. A one-day o
ld, 36 weeks' gestation newborn developed electromechanical dissociati
on after receiving an intravenous bolus of amiodarone for rapid atrial
flutter. Judicious use of amiodarone is recommended.