COMPUTER-SIMULATION OF TRANSPORT PROCESSES IN BIOSENSOR MICROREACTORS

Microelectronic ferment reactors are finding increasing employment as base elements of biosensor matrices. In this work, a computer simulati on of a microelectronic reactor based on ion-sensitive elements, such as transistor or electrolyte-insulator-semiconductor structure, is pre sented. Our objective involved elucidation of quantitative relations b etween the sensor design and its characteristics. The computer simulat ion is performed for different versions of both enzyme carriers and th eir positions in the microreactor cell. The results of simulation enab led us to optimise both design and all-over dimensions of the microrea ctor. The principal sensor parameters (such as response rate, amplitud e and time lag) are calculated for the optimum cell. A comparison betw een the calculated models and the corresponding experimental results o btained with the help of considered types of microreactors is carried out. (C) 1998 Elsevier Science S.A. All rights reserved.