Lm. Ortegamora et al., CONTROLLED FIELD EFFICACY OF INJECTABLE MOXIDECTIN AGAINST NATURALLY ACQUIRED PSOROPTIC MANGE IN SHEEP, Small ruminant research, 29(3), 1998, pp. 271-276
Twenty-one ewes naturally infected with Psoroptes ovis were allocated
into three groups of 7 animals each. Animals in group A were kept as u
ntreated controls. Animals in groups B and C were treated on day 0 and
on day 0 and +10, respectively with 1% injectable moxidectin at a dos
e of 0.2 mg/kg body weight (b.w.). In group B, efficacy based on mite
count reduction, ranged from 22.1% on day + 7 to 97.1% obtained on day
+ 56. In group C, this ranged from 19.4% on day +7 to greater than 90
% from days +42 to +56. Active lesions produced by P. ovis remained es
sentially unchanged through the trial in the untreated animals. In gro
up B, the percentage of efficacy based on reduction of lesions was bet
ween 60-90% until day +35 and was higher than 90% at the last three sa
mpling dates (+42, +49 and +56). In group C, the reduction of lesions
was between 70-90% from days +7 to +21, greater than 97% on days + 28
and +35 and was 100% from days +42 to +56. The high reduction of mites
and disappearance (group C) or significant decrease (group B) of clin
ical signs make moxidectin effective drug in the control of psoroptic
mange in sheep. (C) 1998 Elsevier Science B.V. All rights reserved.