ENZYMATIC RESOLUTION OF (+ -)-THREO-METHYLPHENIDATE/

Authors
PRASHAD M HAR D REPIC O BLACKLOCK TJ GIANNOUSIS P
Citation
M. Prashad et al., ENZYMATIC RESOLUTION OF (+ -)-THREO-METHYLPHENIDATE/, Tetrahedron : asymmetry, 9(12), 1998, pp. 2133-2136
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
12
Year of publication
1998
Pages
2133 - 2136
Database
ISI
SICI code
0957-4166(1998)9:12<2133:ERO(->2.0.ZU;2-K
Abstract
The resolution of (+/-)-threo-methylphenidate by enzymatic hydrolysis with alpha-chymotrypsin or subtilisin carlsberg to afford (2S,2'S)-(-) -threo and (2R,2'R)-(+)-threo-methylphenidate hydrochlorides in high e nantiomeric purities is described. (C) 1998 Elsevier Science Ltd. All rights reserved.