SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY-ELECTROPHORESIS PART 8 - BETA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT

Authors
LIN B ZHU X WUERTHNER S EPPERLEIN U KOPPENHOEFER B
Citation
B. Lin et al., SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY-ELECTROPHORESIS PART 8 - BETA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT, Talanta, 46(4), 1998, pp. 743-749
Citations number
15
Categorie Soggetti
Chemistry Analytical
Journal title
Talanta
ISSN journal
00399140 → ACNP
Volume
46
Issue
4
Year of publication
1998
Pages
743 - 749
Database
ISI
SICI code
0039-9140(1998)46:4<743:SOEODB>2.0.ZU;2-S
Abstract
As part of a comprehensive screening program on the separation of chir al drugs by capillary zone electrophoresis: we have investigated the e nantio-separation of 54 drug racemates with beta-cyclodextrin as a chi ral solvating agent (CSA), thus complementing previous studies on 34 d rug racemates. Fourteen out of the 54 analytes investigated have been separated into the enantiomers, yielding an overall success rate of 24 .4% for 86 drug racemates investigated in total. (C) 1998 Elsevier Sci ence B.V. All rights reserved.