In this paper, we will prove that every derivation of completely distr
ibutive subspace lattice (CDS)algebras on Banach space is automaticall
y continuous. This is new even in the Hilbert space case. As an applic
ation of this result, we obtain that every additive derivation bf nest
algebras on Banach spaces is inner. We will also prove that every iso
morphism between nest algebras on Banach space is automatically contin
uous, and in addition, is spatial.