This article explores the risk factors for the development of diarrhea
. Preventive strategies include education and chemoprophylaxis with bi
smuth subsalicylate-containing compounds or antimicrobial agents. Trea
tment options include attapulgite, bismuth subsalicylate-containing co
mpounds, loperamide, antimicrobial agents, and the combination of lope
ramide and an antimicrobial agent. New strategies include nonabsorbed
antimicrobial agents and a calmodulin inhibitor. Vaccines against ente
rotoxigenic Escherichia coli and Shigella are being evaluated.