IMMUNOADSORPTION THERAPY IN GUILLAIN-BARRE-SYNDROME

A 12-year-old boy rapidly developed Guillain-Barre syndrome (GBS) afte r Campylobacter jejuni enteritis, Electrophysiologic studies suggested that demyelination was dominant, and serum anti-C, jejuni :Ind both I gG and IgM anti-GM1 antibodies were significantly elevated. The patien t was treated three times with immunoadsorption therapy using a trypto phan-immobilized column. The volume of treated plasma in each session was about 2 L, His blood pressure was maintained within normal range w ith the use of 5% albumin preparations and etilefrine hydrochloride, H is clinical and electrophysiologic findings began to recover shortly a fter therapy, with a decrease in the levels of serum IgG and IgM anti- GMS antibodies. This immunoadsorption therapy should be considered for anti-GM1 antibody-associated GBS, (C) 1998 by Elsevier Science Inc. A ll rights reserved.