ACUTE TRYPTOPHAN DEPLETION ATTENUATES THE PROLACTIN RESPONSE TO D-FENFLURAMINE CHALLENGE IN HEALTHY-HUMAN SUBJECTS

Authors
COCCARO EF KAVOUSSI RJ COOPER TB HAUGER R
Citation
Ef. Coccaro et al., ACUTE TRYPTOPHAN DEPLETION ATTENUATES THE PROLACTIN RESPONSE TO D-FENFLURAMINE CHALLENGE IN HEALTHY-HUMAN SUBJECTS, Psychopharmacology, 138(1), 1998, pp. 9-15
Citations number
41
Categorie Soggetti
Neurosciences,Psychiatry,"Pharmacology & Pharmacy
Journal title
Psychopharmacology → ACNP
Volume
138
Issue
1
Year of publication
1998
Pages
9 - 15
Database
ISI
SICI code
Abstract
Prolactin responses to d-fenfluramine (d-FEN) Challenge (0.5 mg/kg PO) were examined after pretreatment with and without acute tryptophan de pletion (ATD) in six physically healthy male volunteers. Compared to p retreatment with SHAM-ATD, ATD pretreatment attenuated the PRL respons e to d-FEN Challenge in all subjects. These data suggest that PRL resp onses to d-FEN challenge reflect to a substantial degree the activity of newly synthesized 5-HT.