EFFECT OF SEROTONERGIC AGENTS ON ADENOSINE A(2) RECEPTOR-MEDIATED CATALEPSY IN MICE

The effect of serotonergic agents was studied on the adenosine A(2) re ceptor agonist NECA-induced catalepsy in mice. The 5-HT releaser fenfl uramine, the 5-HT1A agonist 8-OH-DPAT, the 5-HT2A/1C receptor agonist DOI and the 5-HT2A/1C receptor antagonists ketanserin and mianserin re versed NECA-induced catalepsy. p-MPPI and ketanserin reversed the anti cataleptic actions of 8-OH-DPAT and DOI, respectively. Further, the 5- HT reuptake inhibitor fluoxetine, the 5-HT1B/1C receptor agonist TFMPP , the 5-HT synthesis inhibitor p-CPA, the selective 5-HT1A receptor an tagonist p-MPPI, the 5-HT1A/1B receptor antagonist pindolol and the 5- HT3 receptor antagonist LY 278, 584 had no effect on NECA-induced cata lepsy. The anticataleptic action of fenfluramine was not affected by p retreatment with p-CPA. In p-CPA treated rats, ketanserin did not affe ct the anticataleptic effect of fenfluramine, whereas p-MPPI partially reversed this effect. It is concluded that modulation of serotonergic neurotransmission at 5-HT1A and 5-HT2A/1C receptors affects the catal eptic action of experimental antipsychotic agents with adenosine At re ceptor agonistic activity.