GENERATION OF TUMOR-SPECIFIC CYTOTOXIC T-LYMPHOCYTES AND MEMORY T-CELLS BY IMMUNIZATION WITH TUMOR-DERIVED HEAT-SHOCK-PROTEIN GP96

Tumor-derived heat shock proteins have been shown previously to elicit specific prophylactic immunity to cognate tumors. Here we establish t hat administration of gp96 results in generation of tumor-specific cyt otoxic T lymphocyte response in addition to protective immunity. In on e instance, gp96 preparations are shown to elicit an immune response a gainst a tumor; where intact tumor cells are unable to do so. Finally, our results indicate that gp96 preparations elicit a memory T cell re sponse that is capable of being recalled.