Gm. Weiner et al., SUCCESSFUL TREATMENT OF NEONATAL ARTERIAL THROMBOSES WITH RECOMBINANTTISSUE-PLASMINOGEN ACTIVATOR, The Journal of pediatrics, 133(1), 1998, pp. 133-136
Seven newborns were treated with recombinant tissue plasminogen activa
tor for arterial thromboses. Complete lysis occurred in four of seven
and partial in two of seven patients. Serious bleeding complications w
ere observed in two of seven patients. This and published experience s
uggest that successful lysis with recombinant tissue plasminogen activ
ator occurs in most patients and that hemorrhagic complications are un
usual but not rare.