THE OUTCOME OF PATIENTS WITH HYPOGAMMAGLOBULINEMIA IN INFANCY AND EARLY-CHILDHOOD

A 10-year prospective cohort study followed the evolution of antibodie s in children less than 4 years of age with hypogammaglobulinemia. Thr ee patterns were identified: in group 1, immunoglobulins and antibody production normalized; in group 2, patients continued to have low IgG levels; and in group 3, IgG levels normalized but antibody levels were transient. Statistical analysis showed that invasive infection or low tetanus antibodies at presentation were associated with the developme nt of significant humoral immunodeficiency.