T. Yambe et al., DEVELOPMENT OF TOTAL ARTIFICIAL-HEART WITH ECONOMICAL AND DURABILITY ADVANTAGES, International journal of artificial organs, 21(5), 1998, pp. 279-284
To develop a total artificial heart (TAH) pump system, we created a de
sign paying particular attention to durability and cost. We adopted a
pneumatically driven sac type artificial heart, where the configuratio
n of the sac was decided according to the methodology of flow visualiz
ation. Ifs configuration is almost round to achieve as little stagnati
on as possible and a low turbulent flow. The main body of the sac was
made using polyvinyl chloride (PVC) paste. The paste was poured into a
n external mold, and heated in a hot air drying oven. Coating was perf
ormed using polyurethane. The basic performance of this pump system wa
s tested using a model circulation circuit, and a fitting study throug
h acute animal experiment, using a healthy adult goat, was carried out
. As for the TAH produced experimentally a pump output exceeding 5.0 l
/min in the model circulation circuit was provided. Implantation in th
e internal pleural cavity of a healthy adult goat, 55 kg in weight, pr
oved possible and quite easy in comparison. It is thought that a more
refined design in the connector part is desirable. Furthermore, a chro
nic experiment with the TAH will be carried out, and examination will
need to be repeated in the future.