REVERSIBLE DIABETES-MELLITUS DURING GROWTH-HORMONE THERAPY IN CHRONIC-RENAL-FAILURE

A 12-year-old girl with short stature due to idiopathic Fanconi syndro me and chronic renal failure was treated with recombinant human growth hormone (rhGH). Then was no family history of diabetes mellitus and t he glucose tolerance before treatment was normal. Intravenous glucose tolerance tests were performed before, during and after treatment. Two months after starting rhGH the early phase of insulin secretion (1-+3 -min values) was diminished, and the patient developed manifest diabet es mellitus with hyperglycemia and an elevated hemoglobin Ale. Followi ng discontinuation of rhGH, glucose tolerance slowly returned to norma l.