RENAL TUBULAR DYSGENESIS IN TWINS

In a fetal autopsy series, we have explored the occurrence of renal tu bular dysgenesis in twins. Renal tubular dysgenesis was found exclusiv ely among those monozygotic twins with evidence of twin transfusion sy ndrome, particularly in those donor twins with oligohydramnios and gro wth restriction. We infer that hypotension in the donor twin of the tw in transfusion syndrome pair is responsible for the failure of proxima l convoluted tubule differentiation, and the disturbance of renal func tion is manifested as oligohydramnios prenatally, and either oliguria or tubular dysfunction postnatally.