STREPTOMYCES PNEUMONIA IN A PATIENT WITH HUMAN-IMMUNODEFICIENCY-VIRUSINFECTION - CASE-REPORT AND REVIEW OF THE LITERATURE ON INVASIVE STREPTOMYCES INFECTIONS

Streptomyces species are most widely known for their production of ant imicrobial substances and, apart from mycetoma, have rarely been repor ted as a cause of infection. We describe a patient with early human im munodeficiency virus infection who presented with fever, cough, and no dular pulmonary infiltrates. Open lung biopsy revealed necrotic tissue and a sulfur granule; aerobic bacterial cultures yielded Streptomyces species. The patient was treated successfully with clarithromycin for 6 months. We review the clinical presentation and treatment of invasi ve streptomyces infections.