PAPULAR-PURPURIC GLOVES AND SOCKS SYNDROME-ASSOCIATED WITH ACUTE PARVOVIRUS B19 INFECTION - CASE-REPORT AND REVIEW

The papular-purpuric gloves and socks syndrome (PPGSS) was first descr ibed in 1990. This syndrome is characterized by fever, acral pruritus, edema, petechiae, and oral erosions. Subsequently, parvovirus B19 has been implicated, in most cases, as the causative agent of this syndro me. To date, with two exceptions, all published cases of PPGSS have be en from Europe and the Middle East and have been mainly reported in th e dermatology literature. Herein, we report what we believe to be only the second case of documented parvovirus B19-associated PPGSS occurri ng in the United States. The patient presented with the typical clinic al syndrome, and the diagnosis of acute parvovirus B19 infection was d ocumented by serial serologies that demonstrated development of IgM an tibody to virus during the acute phase of infection and seroconversion to IgG antibody in the convalescent period. We then review the existi ng literature on this unusual syndrome and its association with parvov irus B19.