DETERMINATION OF NIFEDIPINE IN HUMAN PLASMA BY FLOW-INJECTION TANDEM MASS-SPECTROMETRY

Authors
DANKERS J VANDENELSHOUT J AHR G BRENDEL E VANDERHEIDEN C
Citation
J. Dankers et al., DETERMINATION OF NIFEDIPINE IN HUMAN PLASMA BY FLOW-INJECTION TANDEM MASS-SPECTROMETRY, Journal of chromatography B. Biomedical sciences and applications, 710(1-2), 1998, pp. 115-120
Citations number
9
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography B. Biomedical sciences and applications
ISSN journal
13872273 → ACNP
Volume
710
Issue
1-2
Year of publication
1998
Pages
115 - 120
Database
ISI
SICI code
0378-4347(1998)710:1-2<115:DONIHP>2.0.ZU;2-A
Abstract
For use in clinical studies, a fast and sensitive assay method was dev eloped for the determination of nifedipine in human plasma samples. Th e assay method is based on tandem mass spectrometry detection (HPLC-MS -MS). The effect of flow injection as well as HPLC separation on the r esults of the nifedipine determination were evaluated. The limit of qu antification is 0.5 ng/ml and the accuracy (as determined by spiking r ecovery) was found to be good. (C) 1998 Elsevier Science BN. All right s reserved.