IODINE-123-METAIODOBENZYLGUANIDINE SPECT OF REGIONAL CARDIAC ADRENERGIC DENERVATION IN BRUGADA-SYNDROME

We present the case of 44-yr-old man who presented syncope with ventri cular tachycardia in the setting of Brugada syndrome. In addition to t he electrocardiographic evidence of the syndrome and the absence of ap parent structural heart disease, clear defects of myocardial neuronal metaiodobenzylguanidine (MIBG) uptake on MIBG SPECT imaging also were found in inferior, apical and septal walls. Thallium-201 SPECT distrib ution was homogeneous along the left ventricle. Thus, cardiac MIBG sci ntigraphy provides information about left ventricular dysinnervation i n a patient with Brugada syndrome, enhancing the clinical utility of m yocardial MIBG SPECT imaging in life-threatening ventricular arrhythmi as.