PHARMACOKINETICS OF IFOSFAMIDE AND SOME METABOLITES IN CHILDREN

Authors
KAIJSER GP DEKRAKER J BULT A UNDERBERG WJM BEIJNEN JH
Citation
Gp. Kaijser et al., PHARMACOKINETICS OF IFOSFAMIDE AND SOME METABOLITES IN CHILDREN, Anticancer research, 18(3B), 1998, pp. 1941-1949
Citations number
24
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
18
Issue
3B
Year of publication
1998
Pages
1941 - 1949
Database
ISI
SICI code
0250-7005(1998)18:3B<1941:POIASM>2.0.ZU;2-O
Abstract
The pharmacokinetics of ifosfamide and some metabolites in children wa s investigated. The patients received various doses of ifosfamide, mos tly by continuous infusion, over several days. The penetration of ifos famide and its metabolites into the cerebrospinal fluid was also studi ed in foul cases. Ifosfamide and 4-hydroxyifosfamide pass the blood-br ain barrier, reaching cerebrospinal fluid concentrations that are almo st as high as plasma concentrations.