IMPORTANCE OF DETAILED ADJUSTMENT FOR SMOKING WHEN COMPARING HOSPITALIZATION AND MORTALITY IN MEN AND WOMEN IN A DANISH POPULATION STUDY

Mortality from smoking-related diseases is rising steeply among women. Although most studies recognize that smoking habits differ between me n and women, this knowledge is seldom applied when studying gender dif ferences. Based on two large population studies comprising almost 16,0 00 study subjects, we illustrate the importance of adjusting for smoki ng in detail when comparing hospitalization and mortality between men and women. Adjusting for smoking as a dichotomous variable, age-adjust ed mortality risk during 16 years follow-up was 80% higher for men tha n women. Adjusting for smoking in detail significantly reduced men's e xcess risk to 50%. The risk of hospitalization for chronic obstructive pulmonary disease was 50% higher for men when adjusting for smoking a s a dichotomous variable, whereas with full adjustment the risk was re versed to a significantly increased risk for women of 20%. We conclude , that when comparing smoking-related morbidity in men and women, smok ing habits must be adjusted for in more detail than is usually the cas e.