TRANSDUCING HEDGEHOG - THE STORY SO FAR

The secreted proteins of the Hedgehog family have been implicated in m any different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle d evelopment, limb morphogenesis and the specification of different neur onal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause of a number of tumours in humans including basal cell carcinomas (BCCs) and primitive neurec todermal tumours (PNETs). Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease.