HYDROLYSIS OF PHYTIC ACID BY MICROWAVE TREATMENT - APPLICATION TO PHYTIC ACID ANALYSIS IN PHARMACEUTICAL PREPARATIONS

Authors
MARCH JG GRASES F SALVADOR A
Citation
Jg. March et al., HYDROLYSIS OF PHYTIC ACID BY MICROWAVE TREATMENT - APPLICATION TO PHYTIC ACID ANALYSIS IN PHARMACEUTICAL PREPARATIONS, Microchemical journal (Print), 59(3), 1998, pp. 413-416
Citations number
11
Categorie Soggetti
Chemistry Analytical
Journal title
Microchemical journal (Print) → ACNP
ISSN journal
0026265X
Volume
59
Issue
3
Year of publication
1998
Pages
413 - 416
Database
ISI
SICI code
0026-265X(1998)59:3<413:HOPABM>2.0.ZU;2-#
Abstract
The acid hydrolysis of phytic acid in a Teflon reactor using a domesti c microwave oven has been studied and compared with other reported pro cedures. Ln 0.44 M HCl quantitative hydrolysis was achieved with six h earing stages of 2 min each. A lower yield was obtained with H2SO4 and HNO3. The analytical use of this hydrolysis to determine phytic acid by indirect determination of phosphate has been demonstrated by analys is of three pharmaceutical formulations. No sample pretreatment other than obtaining a homogeneous suspension was necessary. (C) 1998 Academ ic Press.