INTRACRANIAL HYPERTENSION IN A NEWBORN TR EATED WITH QUINOLONE

BACKGROUND: Fluoroquinolones have not received administrative authoriz ation for use in children, but because of multiresistant pathogens in neonatal intensive care, floroquinolones may be the only alternative C ASE REPORT: A premature infant exclusively nourished by parenteral nut rition developed enterobacteria sepsis. Ceftazidine was given initiall y but resistance led to the prescription of fluoroquinolone. Signs of intracranial hypertension developed 3 days after onset of fluoroquinol one treatment and regressed 48 hours after its withdrawal. DISCUSSION: The main potential adverse effects with fluoro-quinone in the newborn are arthropahy, photosensitivity discoloration oi the teeth and neuro logical disorders. Intracranial hypertension is a known complication o f nalidixic add both in adults and children, but to our knowledge has not been previously with floroquinolone in the newborn. (C) 1998, Mass on, Paris.