G-PROTEIN-COUPLED RECEPTOR KINASE-2 (GRK2) - MECHANISMS OF REGULATIONAND PHYSIOLOGICAL FUNCTIONS

Authors
ARAGAY AM RUIZGOMEZ A PENELA P SARNAGO S ELORZA A JIMENEZSAINZ MC MAYOR F
Citation
Am. Aragay et al., G-PROTEIN-COUPLED RECEPTOR KINASE-2 (GRK2) - MECHANISMS OF REGULATIONAND PHYSIOLOGICAL FUNCTIONS, FEBS letters, 430(1-2), 1998, pp. 37-40
Citations number
55
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
430
Issue
1-2
Year of publication
1998
Pages
37 - 40
Database
ISI
SICI code
0014-5793(1998)430:1-2<37:GRK(-M>2.0.ZU;2-D
Abstract
G protein-coupled receptor kinase 2 (GRK2) plays a key role in determi ning the rate and extent of G protein-coupled receptor (GPCR) desensit ization and resensitization, Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The imp ortant physiological function of GRK2 as a modulator of the efficacy o f GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors. (C) 1998 Federation of European Bio chemical Societies.