EMOLLIENT THERAPY IN ATOPIC-DERMATITIS - REDISCOVERING THE BENEFITS OF EMOLLIENT THERAPY IN ECZEMA

Dry skin is a characteristic feature of atopic dermatitis, The dryness probably results from a depletion of hydrophilic molecules leading to less water in the stratum corneum, insufficient lipids in the stratum corneum and other abnormalities related to protein and lipid synthesi s. This epidermal defect can disrupt the integrity of the skin in its role as a barrier against adverse external agents, The concept of a ba rrier cream should, therefore, probably be applied to atopic dermatiti s in terms of prevention and treatment. Emollients improve the elastic ity of the stratum corneum, reduce painful fissuring and aid with desq uamation. Studies on the efficacy of emollients show an improved trans epidermal water loss which correlates well with the improvement of ski n barrier function. There is a strong need to tailor specific emollien ts for use in patients with atopic dermatitis, To strengthen complianc e, new products should be evaluated for irritation and sensitivity, wi th individual preference and the attractiveness of the product taken i nto account. To improve treatment in the future, studies must attempt to identify the barrier defects in atopic dermatitis on a biochemical and molecular level.