The World Health Organization Collaborative Study on Psychological Pro
blems in General Health Care examined the form and frequency of, and d
isability associated with, psychiatric disorders in primary care atten
ders in 14 countries worldwide. This large multicenter study showed th
at psychiatric disorders are frequent (24%) among primary healthcare a
ttenders and that significant disability is associated with the mental
illness. We present further data from this study, focusing on the com
orbidity of psychiatric disorders and the relevance of panic attacks i
n the primary care setting. Panic disorder is frequently comorbid with
depression and this comorbid condition represents a severe form of me
ntal illness. Patients diagnosed with both panic disorder and depressi
on are more likely to have a long-lasting disorder that has an increas
ed severity, results in higher disability levels and is associated wit
h increased suicidality. Panic attacks are indicative of the presence
of a depressive disorder, an anxiety disorder or a subthreshold diagno
sis in 99% of patients with current panic attacks. A high symptomatic
severity and disability, and increased suicide risk mere found in subt
hreshold cases, particularly if associated with depressive episodes. T
hus, panic attacks, which are readily recognized, are characteristic o
f psychiatric illness and should indicate a high probability that trea
tment is needed. (C) 1998 Lippincott-Raven Publishers.