2-DIMENSIONAL 220 MHZ FOURIER-TRANSFORM EPR IMAGING

In the last decade radiofrequency continuous-wave EPR spectrometers ha ve been developed to detect and localize free radicals in vivo. Only r ecently, pulsed radiofrequency EPR spectrometers have been described f or imaging applications with small samples. In the present work, we sh ow the first two-dimensional image obtained at 220 MHz on a large phan tom (40 ml) that simulates typical conditions of in vivo EPR imaging. This pulsed EPR apparatus has the potential to make the time required for three-dimensional imaging compatible with the biological half-life of normally used paramagnetic probes.