SULFATED HYALURONIC ACIDS - A CHEMICAL AND BIOLOGICAL CHARACTERIZATION

Citation
A. Magnani et al., SULFATED HYALURONIC ACIDS - A CHEMICAL AND BIOLOGICAL CHARACTERIZATION, Polymer international, 46(3), 1998, pp. 225-240
Citations number
53
Categorie Soggetti
Polymer Sciences
Journal title
ISSN journal
09598103
Volume
46
Issue
3
Year of publication
1998
Pages
225 - 240
Database
ISI
SICI code
0959-8103(1998)46:3<225:SHA-AC>2.0.ZU;2-A
Abstract
This review focuses on the possibility of modifying hyaluronic acid by the insertion of sulphate groups in order to obtain heparin-like comp ounds with controllable properties. In particular, the physicochemical and biological behaviour of sulphated hyaluronic acid (HyalS(x)) with various degrees of sulphation and different molecular weights has bee n particularly investigated. The mobilization of endothelial cells was investigated by the use of copper(II) complexes with HyalS(x) and the results were compared with those from the corresponding complex with heparin. New materials containing HyalS(x) are proposed for biomedical applications. (C) 1998 SCI.