LOW-FREQUENCY ELECTROMAGNETIC-FIELDS DO NOT AFFECT CELL-GROWTH, ERYTHROID-DIFFERENTIATION, AND VIRUS PRODUCTION IN VARIANT LINES OF UNTREATED AND DIMETHYL SULFOXIDE-TREATED FRIEND-ERYTHROLEUKEMIA CELLS
Rp. Revoltella et al., LOW-FREQUENCY ELECTROMAGNETIC-FIELDS DO NOT AFFECT CELL-GROWTH, ERYTHROID-DIFFERENTIATION, AND VIRUS PRODUCTION IN VARIANT LINES OF UNTREATED AND DIMETHYL SULFOXIDE-TREATED FRIEND-ERYTHROLEUKEMIA CELLS, Electro- and magnetobiology, 12(2), 1993, pp. 135-146
We compared the effects of exposing to low-frequency (50 Hz) sinusoida
l electromagnetic fields (EMF) (magnetic field amplitude of 200 mu T)
four variant Friend erythroleukemia (FL) cell lines with regard to the
ir capacity to proliferate, synthesize hemoglobin (Hb), and produce vi
rus proteins, before and after treatment with dimethyl sulfoxide (DMSO
). Our results confirm previous data indicating that: (1) clonal FL ce
lls are variable in their growth, differentiation, and viral propertie
s; (2) erythroid differentiation and virus production are under separa
te control; (3) cell replication is apparently necessary for virus pro
duction. When FL cells were exposed to EMF, no significant difference
was observed in cell counts, induction of Hb synthesis, or virus produ
ction and release, comparing untreated and EMF-treated cell cultures.