For centuries, the evolution of liver and portal surgery has been a ra
ther slow process. While important anatomic details were already known
in the 17th century, the first successful partial liver resection - w
hich took place in 1888 - required the invention of anaesthesia and an
tisepsis as well as progress in experimental medicine in the 19th cent
ury. Development of blood donation, anaesthesiology and intensive care
medicine and a deepened understanding of liver anatomy in the first h
alf of the 20th century ushered in the modern era of liver surgery. Wi
th liver transplantation, split liver transplantation and the living-d
onor concept this has reached an unforeseen climax.