CRYSTAL-STRUCTURE OF THE FIRST 3 DOMAINS OF THE TYPE-1 INSULIN-LIKE-GROWTH-FACTOR RECEPTOR

Authors
GARRETT TPJ MCKERN NM LOU MZ FRENKEL MJ BENTLEY JD LOVRECZ GO ELLEMAN TC COSGROVE LJ WARD CW
Citation
Tpj. Garrett et al., CRYSTAL-STRUCTURE OF THE FIRST 3 DOMAINS OF THE TYPE-1 INSULIN-LIKE-GROWTH-FACTOR RECEPTOR, Nature, 394(6691), 1998, pp. 395-399
Citations number
30
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Nature → ACNP
ISSN journal
00280836
Volume
394
Issue
6691
Year of publication
1998
Pages
395 - 399
Database
ISI
SICI code
0028-0836(1998)394:6691<395:COTF3D>2.0.ZU;2-6
Abstract
The type-1 insulin-like growth-factor receptor (IGF-1R) and insulin re ceptor (IR) are closely related members of the tyrosine-kinase recepto r superfamily(1). IR is essential for glucose homeostasis(2), whereas IGF-1R is involved in both normal growth and development and malignant transformation(3). Homologues of these receptors are found in animals as simple as cnidarians(4).