COMPUTER-AIDED ORGANIC-SYNTHESIS - SESAM - A SIMPLE PROGRAM TO UNRAVEL HIDDEN RESTRUCTURED STARTING MATERIALS SKELETA IN COMPLEX TARGETS

We describe the SESAM program whose aim is to help the chemist in expl oring new synthetic strategies for complex structures by locating simp le, non-obvious but effective starting materials. The program works at the skeletal level and attempts to map simply modified starting mater ials into the skeletal surface of the target. SESAM has been tested on taxol and steroid frameworks.