H. Mcnab et C. Thornley, NEW CHEMISTRY OF PYRROLIZIN-3-ONE - A CONCISE ROUTE TO 3,8-DIDEHYDROHELIOTRIDIN-5-ONE, Journal of the Chemical Society, Chemical Communications, (20), 1993, pp. 1570-1571
1-Substituted 1,2-dihydropyrrolizin-3-ones can be obtained from pyrrol
izin-3-one 2 by conjugate nucleophilic addition or electrophilic addit
ion reactions; the 1-chloro compound 9 obtained by the latter method i
s used as a key intermediate in a six-step synthesis of the title comp
ound 3 from 4-acetoxymethylpyridine-N-oxide.