SYNTHESES OF 1,5-BENZOTHIAZEPINES, PART XVI - SYNTHESES OF 8-ETHOXY FLUORO-2-CARBOXY-4-(FLUORINATED ARYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPINES AS PROSPECTIVE CARDIOVASCULAR AGENTS/

Syntheses of fluorinated 8-ethoxy/fluoro-2-carboxy-4-substituted aryl- 2,3-dihydro 1,5-benzothiazepines having substitutents as chloro, methy l and trifluoromethyl have been achieved by the reaction of 5-ethoxy/- fluoro-2-aminobenzenethiols with fluorinated 3-substituted benzoyl-2-p ropenoic acids in toluene with catalytic amount of trifluoroacetic aci d. The progress of the reactions was monitored by t.l.c. studies. Stru ctures of the title compounds are established by IR, PMR and mass spec tral studies and microestimation data of nitrogen.