C-FOS EXPRESSION IN NMDA RECEPTOR-CONTAINED NEURONS IN SPINAL-CORD INA RAT MODEL OF INFLAMMATION - A DOUBLE IMMUNOCYTOCHEMICAL STUDY

Double-labeling techniques were used to demonstrate the nociceptive ac tivation of NMDA receptor-contained neurons in spinal dorsal horn by u sing c-Fos immunoreactivity as an indicator of this activation in a ra t model of inflammation. About 25% and 55% of the c-Fos-immunoreactive neurons that were found in laminae I-II and lamina V showed NMDA rece ptor immunoreactivity, while about 4% and 11% of NMDA-receptor immunor eactive neurons in these two regions showed c-Fos immunoreactivity, re spectively. The implication of the results was discussed. (C) 1998 Els evier Science B.V. All rights reserved.