Weight loss occurs commonly in elderly individuals, and is associated
with functional decline and mortality. A 10% loss of body weight over
10 years is consistently associated with increased mortality and funct
ional decline. A 4% body weight loss over 1 year should trigger a sear
ch for causes, which commonly include depression, cancers, benign gast
rointestinal conditions, and medication toxicity. To evaluate weight l
oss, physicians should distinguish between four problems: anorexia, dy
sphagia, weight loss despite normal intake, or socioeconomic problems.
In most cases, the cause of weight loss is identified by a thorough h
istory, a targeted physical examination, and a simple laboratory evalu
ation. Assessment should include evaluation of functional and nutritio
nal status. Management should include correction of potential causes a
nd nutritional supplementation.