Pyoderma gangrenosum is an uncommon ulcerative skin disorder that is o
ften associated with underlying systemic diseases, the most common of
which is inflammatory bowel disease. We report an illustrative case of
a 36-year-old woman with pyoderma gangrenosum occurring at surgical s
ites and at sites of trauma. She had associated Crohn disease. Multipl
e surgical procedures were performed on this patient, without improvem
ent. Pyoderma gangrenosum can mimic a necrotizing soft tissue infectio
n. Early recognition of the characteristic lesion may prevent unnecess
ary operations and facilitate effective control with appropriate medic
al therapy.