Ml. Zhao et Rb. Fritz, ACUTE AND RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN IL-4-DEFICIENT AND ALPHA BETA-T-CELL-DEFICIENT C57BL/6 MICE/, Journal of neuroimmunology, 87(1-2), 1998, pp. 171-178
Experimental autoimmune encephalomyelitis follows a chronic relapsing
course in several inbred strains of mice. To address the role of T cel
ls in recovery and relapse, the clinical course of EAE was compared in
C57BL/6 (B6) normal and immunodeficient mice following active immuniz
ation with MOG p35-55 or adoptive transfer of encephalitogenic peptide
-specific T cell lines. The course of actively-induced EAE in B6 wild-
type and IL-4 -/- mice was similar. B6 TL-4 -/- mice recovered normall
y from acute passive EAE, but did not relapse in contrast to wild-type
B6 mice. EAE was progressive in B6 RAG - / - and alpha/beta TCR -/ -
mice, but the disease course could be arrested by infusion of normal s
pleen cells. When non-activated MOG peptide-specific T cells were tran
sferred to wild-type or alpha/beta TCR -/- mice, spontaneous disease e
nsued in the mutants only. (C) 1998 Elsevier Science B.V. All rights r
eserved.