OVULATION INDUCTION WITH PULSATILE GNRH IN A PATIENT WITH ANOVULATIONOF HYPOTHALAMIC ORIGIN AND CENTRAL DIABETES-INSIPIDUS

Patients with diabetes insipidus (DI) are at high risk for dehydration , hypernatremia and hemodynamic instability. Ovarian hyperstimulation syndrome (OHSS) likewise has negative effects on electrolyte balance. If ovulation induction is required in a patient with DI, there is thus a strong argument for avoiding techniques that increase the risk of O HSS. This paper reports the results of ovulation induction in a patien t with anovulation of hypothalamic origin and central (vasopressin def icit) DI. Ovulation was induced with pulsatile gonadotropin-releasing hormone (GnRH), which induces single-ovule cycles and which does not i ncrease the risk of OHSS. The patient successfully achieved pregnancy after seven ovulatory cycles.